Neuroprotection Methods and Protocols

Neuroprotection Methods and Protocols

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This book examines current research into the role of neuronal death in cell signaling pathways, and its role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. After introducing neurodegenerative, traumatic, and ishemic disorders, the authors cover in vitro and animal systems, and cellular and molecular mechanisms.The Use of Propidium Iodide to Assess Excitotoxic Neuronal Death in Primary Mixed Cortical Cultures Anthony C. Lau, Hong Cui, and Michael ... and the compound used to demonstrate neuroprotection will be the nonspecific NOS inhibitor N-nitro-l-arginine methyl ester (l-NAME). Assessment of neuronal death is accomplished by measuring changes in PI fluorescence using a fluorescent plate reader.

Title:Neuroprotection Methods and Protocols
Author: Tiziana Borsello
Publisher:Springer Science & Business Media - 2007-08-08

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